DNA vaccine mechanistic insight and delivery strategies

DNA vaccines have proved to be potential candidates to be considered as a part of active immunity. These latest generation genetic tools have solved the problems associated with the traditional vaccines. However, there are number of infectious diseases like AIDS, Malaria and Tuberculosis against which no DNA vaccine has been established. This review describes multiple DNA vaccine applications and delivery systems for DNA antigen. Future strategies to improve the efficacy of DNA vaccine like route of administration and novel adjuvants are also discussed